RAMP2 Antibody Summary
| Immunogen |
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human RAMP2. The exact sequence is proprietary.
|
| Localization |
Membrane, Single-pass type I membrane protein
|
| Predicted Species |
Bovine (93%). Backed by our 100% Guarantee.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
RAMP2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (87%), Rat (80%), Pig (86%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for RAMP2 Antibody
- calcitonin receptor-like receptor activity modifying protein 2
- Calcitonin-receptor-like receptor activity-modifying protein 2
- CRLR activity-modifying protein 2
- RAMP2
- receptor (calcitonin) activity modifying protein 2
- receptor (G protein-coupled) activity modifying protein 2
- receptor activity modifying protein 2
- receptor activity-modifying protein 2
- receptor-activity-modifying protein 2
Background
The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CRLR) to the plasma membrane. CRLR, a receptor with seven transmembrane domains, can function as either a calcitonin-gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In the presence of this (RAMP2) protein, CRLR functions as an adrenomedullin receptor. The RAMP2 protein is involved in core glycosylation and transportation of adrenomedullin receptor to the cell surface.