Pax5/BSAP Antibody Summary
| Immunogen |
This antibody is specific for the Middle Region of the target protein.
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| Specificity |
This product is specific for Human PAX5.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PAX5
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody is useful in ELISA, Western Blot and Immunohistochemistry-Paraffin.
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| Publications |
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Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
20mM Potassium Phosphate (pH 7.0) and 0.15M NaCl
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| Preservative |
No Preservative
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| Purity |
Immunogen affinity purified
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Notes
Manufactured by SDIXs proprietary Genomic Antibody Technology™. GAT FAQs.
Alternate Names for Pax5/BSAP Antibody
- B cell specific activator protein
- B-cell-specific transcription factor
- BSAP
- BSAPB-cell lineage specific activator
- paired box 5
- paired box gene 5 (B-cell lineage specific activator protein)
- paired box gene 5 (B-cell lineage specific activator)
- paired box homeotic gene 5
- paired box protein Pax-5
- Pax5
- transcription factor PAX 5
Background
This gene encodes a member of the paired box (PAX) family of transcription factors. The central feature of this gene family is a novel, highly conserved DNA-binding motif, known as the paired box. PAX proteins are important regulators in early development, and alterations in the expression of their genes are thought to contribute to neoplastic transformation. This gene encodes the B-cell lineage specific activator protein that is expressed at early, but not late stages of B-cell differentiation. Its expression has also been detected in developing CNS and testis and so the encoded protein may also play a role in neural development and spermatogenesis. This gene is located at 9p13, which is involved in t(9;14)(p13;q32) translocations recurring in small lymphocytic lymphomas of the plasmacytoid subtype, and in derived large-cell lymphomas. This translocation brings the potent E-mu enhancer of the IgH gene into close proximity of the PAX5 promoter, suggesting that the deregulation of transcription of this gene contributes to the pathogenesis of these lymphomas. Alternatively spliced transcript variants encoding different isoforms have been described but their biological validity has not been determined.