PTP alpha/PTPRA Antibody Summary
| Immunogen |
Synthetic 17 amino acid peptide from cytoplasmic domain of human PTPRA.
|
| Epitope |
cytoplasmic domain of human
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| Specificity |
Human PTPRA. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
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| Predicted Species |
Rat (94%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PTPRA
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Gorilla, Gibbon, Marmoset. Predicted cross-rectivity based on sequence identity: Panda (100%), Elephant (88%), Turkey (88%), Chicken (88%), Xenopus (82%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.1% Sodium Azide
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| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PTP alpha/PTPRA Antibody
- EC 3.1.3.48
- HEPTP
- HLPR
- LRP
- LRPHPTPalpha
- protein tyrosine phosphatase, receptor type, A
- Protein-tyrosine phosphatase alpha
- PTP alpha
- PTPAreceptor type, alpha polypeptide
- PTPase-alpha
- PTPLCA-related phosphatase
- PTPRA
- PTPRL2
- receptor-type tyrosine-protein phosphatase alpha
- RPTPA
- R-PTP-alpha
- tyrosine phosphatase alpha
Background
PTP alpha, a R4 receptor protein tyrosine phosphatase, is implicated in neuron formation, retinal development, cell adhesion, potassium channel regulation, nerve repair, insulin signaling, and cell cycle regulation. PTP alpha activates the Src protein tyrosine kinase during mitosis, resulting in the transition from G2 to mitosis in the cell cycle. PTP alpha is associated with carcinomas of breast, colon, oral squamous cell and prostate. A cytosolic form of PTP alpha, p66 PTP alpha, has recently been isolated. p66 PTP alpha is produced by calpain-mediated proteolytic cleavage and its expression has been detected in nearly all cell types where PTP alpha is expressed. PTP alpha expression has been documented in human neoplastic breast, colon, prostate, and oral tissues, as well as in normal adipose, liver, skeletal muscle, and endothelial cells. ESTs have been isolated from a diverse set of normal and cancerous tissue libraries.