PTK7/CCK4 Antibody Summary
| Immunogen |
Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PTK7. The immunogen is located within amino acids 250 – 300 of PTK7.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PTK7
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PTK7/CCK4 Antibody
- CCK4
- CCK-4
- CCK4Colon carcinoma kinase 4
- colon carcinoma kinase-4
- Protein-tyrosine kinase 7
- Pseudo tyrosine kinase receptor 7
- PTK7 protein tyrosine kinase 7
- PTK7
- Tyrosine-protein kinase-like 7
Background
Protein-tyrosine kinases (PTKs) play important roles in regulating cell proliferation and differentiation during development. One member of the PTK family, PTK7, has been suggested to regulate the planar cell polarity (PCP) pathway in vertebrates and may play a role in neural convergent extension and neural tube closure. PTK7 has also been implicated in the development of cancer. Loss of PTK7 expression was seen in several melanoma cell lines and biopsies. Conversely, high-throughput analysis of acute myeloid leukemia samples showed an increased level of PTK7 expression compared to normal bone marrow and purified CD34+ cells. Multiple isoforms of PTK7 are known to exist.