PRDC/GREM2 Antibody

Product: ABT-751

PRDC/GREM2 Antibody Summary

Immunogen
Carrier-protein conjugated synthetic peptide encompassing a sequence within the C-terminus region of human GREM2. The exact sequence is proprietary.
Localization
Secreted
Specificity
Antibody reactive against peptide, detects immunogen. Further validation in progress.
Predicted Species
Mouse (100%), Rat (100%), Primate (100%). Backed by our 100% Guarantee.
Isotype
IgG
Clonality
Polyclonal
Host
Rabbit
Gene
GREM2
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Western Blot 1:500-1:3000
  • Immunohistochemistry 1:100-1:1000
  • Immunohistochemistry-Paraffin 1:100-1:1000
Application Notes
WB: Detects antigen.
Theoretical MW
19 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Reactivity Notes

Expected cross reactivity based on sequence homology: Rhesus Monkey (100%).

Packaging, Storage & Formulations

Storage
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Buffer
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
Preservative
0.01% Thimerosal
Concentration
0.97 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PRDC/GREM2 Antibody

  • CKTSF1B2
  • CKTSF1B2FLJ21195
  • Cysteine knot superfamily 1, BMP antagonist 2
  • DAN domain family member 3
  • DAND3
  • DAND3Prdc
  • GREM2
  • gremlin 2
  • gremlin 2, cysteine knot superfamily, homolog
  • gremlin-2
  • PRDC
  • PRDCgremlin 2, cysteine knot superfamily, homolog (Xenopus laevis)
  • Protein related to DAN and cerberus

Background

This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. [provided by RefSeq]

PMID: 11741743