PRAK Antibody

Product: Sinapine (thiocyanate)

PRAK Antibody Summary

Immunogen
The immunogen for this product maps to a region between residue 250 and 300 of human mitogen-activated protein kinase-activated protein kinase 5 using the numbering given in entry NP_620777.1 (GeneID 8550).
Clonality
Polyclonal
Host
Rabbit
Gene
MAPKAPK5
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry
  • Immunohistochemistry-Paraffin
  • Immunoprecipitation 2-5 ug/mg lysate

Reactivity Notes

Human

Packaging, Storage & Formulations

Storage
Store at 4C. Do not freeze.
Buffer
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
Preservative
0.09% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for PRAK Antibody

  • EC 2.7.11
  • MAP kinase-activated protein kinase 5
  • MAPK-activated protein kinase 5
  • MAPKAP kinase 5
  • MAPKAPK-5
  • mitogen-activated protein kinase-activated protein kinase 5
  • p38-regulated/activated protein kinase
  • PRAKEC 2.7.11.1

Background

The protein encoded by this gene is a member of the serine/threonine kinase family. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. In vitro, this kinase phosphorylates heat shock protein HSP27 at its physiologically relevant sites. Two alternately spliced transcript variants of this gene encoding distinct isoforms have been reported.

PMID: 8107329