PPP2R2B Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human PPP2R2B. The exact sequence is proprietary.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PPP2R2B
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Expected cross reactivity based on sequence homology: Xenopus laevis (94%), Xenopus tropicalis (94%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.7 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PPP2R2B Antibody
- B55BETA
- FLJ95686
- MGC24888
- PP2A subunit B isoform B55-beta
- PP2A subunit B isoform beta
- PP2A subunit B isoform PR55-beta
- PP2A subunit B isoform R2-beta
- PP2A, subunit B, B-beta isoform
- PP2AB55BETA
- PP2ABBETA
- PP2APR55B
- PP2APR55BETA
- PR2AB55BETA
- PR2ABBETA
- PR2APR55BETA
- PR52B
- PR55BETA
- PR55-BETA
- protein phosphatase 2 (formerly 2A), regulatory subunit B (PR 52), beta isoform
- protein phosphatase 2 (formerly 2A), regulatory subunit B, beta isoform
- protein phosphatase 2, regulatory subunit B, beta
- SCA12
- serine/threonine protein phosphatase 2A, 55 kDa regulatory subunit B, betaisoform
- serine/threonine protein phosphatase 2A, neuronal isoform
- serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B betaisoform
- spinocerebellar ataxia 12
Background
The product of this gene belongs to the phosphatase 2 regulatory subunit B family. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The B regulatory subunit might modulate substrate selectivity and catalytic activity. This gene encodes a beta isoform of the regulatory subunit B55 subfamily. Defects in this gene cause autosomal dominant spinocerebellar ataxia 12 (SCA12), a disease caused by degeneration of the cerebellum, sometimes involving the brainstem and spinal cord, and in resulting in poor coordination of speech and body movements. Multiple alternatively spliced variants, which encode different isoforms, have been identified for this gene. The 5 UTR of some of these variants includes a CAG trinucleotide repeat sequence (7-28 copies) that can be expanded to 66-78 copies in cases of SCA12.