PNK Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human PNK. The exact sequence is proprietary.
|
| Localization |
Nucleus
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| Isotype |
IgG
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| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PNKP
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
57 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Reactivity Notes
Expected cross reactivity based on sequence homology: Mouse (82%), Rat (81%).
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PNK Antibody
- DNA 5-kinase/3-phosphatase
- EIEE10
- Homo sapiens polynucleotide kinase 3-phosphatase (PNKP)
- MCSZ
- PNKbifunctional polynucleotide phosphatase/kinase
- polynucleotide kinase 3-phosphatase
- Polynucleotide kinase-3-phosphatase
Background
Mammalian PNK (also known as PNKP, Polynucleotide kinase 3-phosphatase, Polynucleotide kinase 3-prime-phosphatase, DNA 5-kinase/3-phosphatase and Polynucleotide Kinase) catalyzes the 5- prime phosphorylation of nucleic acids and can have associated 3-prime phosphatase activity, predictive of an important function in DNA repair following ionizing radiation or oxidative damage. PNK is a nuclear protein that is expressed in many tissues with highest expression in spleen and testis, and lowest expression in small intestine.