PMEL17/SILV Antibody (SPM286) [Alexa Fluor® 405] Summary
| Immunogen |
Membranes from a human melanoma metastasis
|
| Localization |
Cytoplasmic
|
| Marker |
Melanoma Marker
|
| Specificity |
By immunohistochemistry, it specifically recognizes a protein in melanocytes and melanomas. This MAb reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin.This Mab labels formalin-fixed, paraffin-embedded melanomas and other tumors showing melanocytic differentiation.
|
| Isotype |
IgG2b Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PMEL
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
|
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for PMEL17/SILV Antibody (SPM286) [Alexa Fluor® 405]
- D12S53EP1
- gp100
- ME20
- ME20-M
- melanocyte protein mel 17
- Melanocyte protein Pmel 17
- Melanocytes lineage-specific antigen GP100
- Melanoma-associated ME20 antigen
- melanosomal matrix protein17
- PMEL17P100
- premelanosome proteinME20M
- SI
- SIL
- silver (mouse homolog) like
- silver homolog (mouse)
- Silver locus protein homolog
- silver, mouse, homolog of
- SILVPmel17