Product: UNC2026 (hydrochloride)
PICALM Antibody Summary
| Immunogen |
Antibody was raised against a 15 amino acid synthetic peptide from near the amino terminus of human PICALM. The immunogen is located within the first 50 amino acids of PICALM.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PICALM
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
PICALM antibody can be used for detection of PICALM by Western blot at 1 – 2 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PICALM Antibody
- CALMclathrin assembly lymphoid-myeloid leukemia
- Clathrin assembly lymphoid myeloid leukemia protein
- CLTHphosphatidylinositol-binding clathrin assembly protein
- LAP
- phosphatidylinositol binding clathrin assembly protein
Background
PICALM, also known as the clathrin assembly lymphoid myeloid leukemia (CALM) protein, co-localizes with clathrin at clathrin-coated areas of the plasma membrane and in the Golgi area, and is thought to be an important component of the coated pit internalization machinery. Fusion proteins involving PICALM have been implicated in acute myeloid and T-cell acute lymphoblastic leukemia. PICALM is also expressed in neurons and is present at the synapse where it facilitates the endocytosis of the synaptic vesicle protein VAMP2. Recent studies have identified variants of PICALM associated with Alzheimers disease and have suggested this protein may play a role in the endocytosis and recycling of the amyloid protein precursor (APP).