PEX5 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human PEX5. The exact sequence is proprietary.
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| Localization |
Cytoplasm, Peroxisome membrane, Peripheral membrane protein
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| Predicted Species |
Guinea Pig (98%), Bovine (97%). Backed by our 100% Guarantee.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PEX5
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| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
|
| Theoretical MW |
71 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
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| Preservative |
0.01% Thimerosal
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for PEX5 Antibody
- FLJ50634
- FLJ50721
- Peroxin-5
- peroxisomal biogenesis factor 5
- Peroxisomal C-terminal targeting signal import receptor
- peroxisomal targeting signal 1 receptor
- peroxisomal targeting signal import receptor
- peroxisomal targeting signal receptor 1
- Peroxisome receptor 1peroxin-5
- PTS1 receptor
- PTS1-BP
- PTS1RFLJ51948
- PXR1peroxisomal targeting signal 1 (SKL type) receptor
Background
The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.