Product: 2-Amino-7-methylheptane
PDGF R beta Antibody (RM0005-4C54) Summary
| Immunogen |
This antibody was produced from a hybridoma (mouse myeloma fused with spleen cells) from a rat immunized with purified mouse PDGF receptor-#226; extracellular domain.
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| Specificity |
PDGF receptor beta (RM0005-4C54)
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| Isotype |
IgG2
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| Clonality |
Monoclonal
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| Host |
Rat
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| Gene |
PDGFRB
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| Purity |
Protein G purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody recognizes mouse PDGF receptor #226; in western blot. No cross reactivity to mouse PDGF receptor #225;.
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
A 0.2 um filtered solution in PBS
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| Preservative |
No Preservative
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| Concentration |
LYOPH
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| Purity |
Protein G purified
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| Reconstitution Instructions |
Reconstitute with 0.5 ml sterilized PBS to a final concentration of 0.2 mg/ml.
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Alternate Names for PDGF R beta Antibody (RM0005-4C54)
- beta-type platelet-derived growth factor receptor
- CD140 antigen-like family member B
- CD140b antigen
- CD140b
- EC 2.7.10
- EC 2.7.10.1
- JTK12
- PDGF R beta
- PDGFR
- PDGFR1
- PDGFRB
- PDGF-R-beta
- platelet-derived growth factor receptor, beta polypeptide
Background
Platelet-derived growth factors (PDGFs) exhibit tyrosine-protein kinase activity and have been implicated in the control of cell proliferation, survival and migration. PDGF receptors, PDGFR-alpha and PDGFR-beta, have 5 extracellular immunoglobulin-like domains and an intracellular tyrosine kinase domain. Upon binding a PDGF, the receptors form homo-and heterodimers. Dimerization of the receptors results in phosphorylation in the complex. More than 10 different SH2-domain-containing molecules have been shown to bind to different autophosphorylation sites in the PDGF-alpha and beta receptors. PDGF alpha receptors are expressed in oligodendrocyte progenitor cells and PDGF beta receptors are expressed on neurons.