PDGF R alpha [p Tyr742] Antibody Summary
| Immunogen |
Synthetic phospho peptide that contains Tyrosine 742 (Human).
|
| Modification |
p Tyr742
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| Localization |
Cell Membrane and Cytoplasmic.
|
| Specificity |
PDGFR beta (50% identity) has not been tested, but is not expected to react.
|
| Predicted Species |
Rat (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
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| Gene |
PDGFRA
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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|
| Application Notes |
WB: Detects a band of approximately 170-185 kDa.
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| Publications |
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Reactivity Notes
Cross-reacts with Human and Mouse. Expected to cross-react with Rat (100% identity with immunogen), Xenopus laevis (Frog) (83% identity with immunogen) due to sequence identity, and PDGFRB is expected to react due to 50% sequence homology. Not yet tested in other species.
Packaging, Storage & Formulations
| Storage |
Store at -80C. Avoid freeze-thaw cycles.
|
| Buffer |
Dulbeccos PBS (pH 7.3) and 1.0 mg/ml
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
0.5 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for PDGF R alpha [p Tyr742] Antibody
- alpha-type platelet-derived growth factor receptor
- CD140 antigen-like family member A
- CD140a antigen
- CD140a
- EC 2.7.10
- EC 2.7.10.1
- MGC74795
- PDGF R alpha
- PDGFR2
- PDGFRA
- PDGFRA/BCR fusion
- PDGF-R-alpha
- platelet-derived growth factor receptor, alpha polypeptide
- rearranged-in-hypereosinophilia-platelet derived growth factor receptor alphafusion protein
- RHEPDGFRA
Background
Platelet derived growth factor receptor (PDGF Receptor) is a transmembrane glycoprotein of 170-185 kDa which undergoes homo or heterodimerization into complexes of alpha and beta subunits upon ligand binding, depending on the isoform of PDGF (PDGF AA, BB or AB) that binds. The phosphorylation of tyrosine residues in the now activated receptor can control multiple signaling events such as actin reorganization, transcription, cell growth, migration and differentiation, and also lead to activation of the Ras, Raf and ERK 1 and 2 pathway.