PCDHGA2 Antibody (2A7) Summary
| Immunogen |
PCDHGA2 (NP_061738, 223 a.a. ~ 332 a.a) partial recombinant protein with GST tag. SGTSRICVKVLDANDNAPVFTQPEYRISIPENTLVGTRILTVTATDADEGYYAQVVYFLEKSPGETSEVFELKSTSGELTIIKDLDYEDATFHEIDIEAQDGPGLLTRA
|
| Localization |
Cell membrane; Single-pass type I membrane protein
|
| Specificity |
PCDHGA2 – protocadherin gamma subfamily A, 2
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
PCDHGA2
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactive against cell lysate and recombinant protein for western blot. It has also been used for RNAi validation and ELISA.
|
Reactivity Notes
Human, Mouse.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
Phosphate buffered saline, pH 7.4
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for PCDHGA2 Antibody (2A7)
- PCDH-GAMMA-A2
- protocadherin gamma subfamily A, 2
- protocadherin gamma-A2
Background
This gene is a member of the protocadherin gamma gene cluster, one of three related clusters tandemly linked on chromosome five. These gene clusters have an immunoglobulin-like organization, suggesting that a novel mechanism may be involved in their regulation and expression. The gamma gene cluster includes 22 genes divided into 3 subfamilies. Subfamily A contains 12 genes, subfamily B contains 7 genes and 2 pseudogenes, and the more distantly related subfamily C contains 3 genes. The tandem array of 22 large, variable region exons are followed by a constant region, containing 3 exons shared by all genes in the cluster. Each variable region exon encodes the extracellular region, which includes 6 cadherin ectodomains and a transmembrane region. The constant region exons encode the common cytoplasmic region. These neural cadherin-like cell adhesion proteins most likely play a critical role in the establishment and function of specific cell-cell connections in the brain. Alternative splicing has been described for the gamma cluster genes.