Product: Ginkgolic Acid (C13:1)
PCDHA8 Antibody Summary
| Immunogen |
This PCDHA8 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 773-800 amino acids from the C-terminal region of human PCDHA8.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PCDHA8
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Reacts with Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.09% Sodium Azide
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| Purity |
Protein A purified
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Alternate Names for PCDHA8 Antibody
- KIAA0345-like 6
- PCDH-ALPHA8
- PCDH-alpha-8
- protocadherin alpha 8
- protocadherin alpha-8
Background
This gene is a member of the protocadherin alpha genecluster, one of three related gene clusters tandemly linked onchromosome five that demonstrate an unusual genomic organizationsimilar to that of B-cell and T-cell receptor gene clusters. Thealpha gene cluster is composed of 15 cadherin superfamily genesrelated to the mouse CNR genes and consists of 13 highly similarand 2 more distantly related coding sequences. The tandem array of15 N-terminal exons, or variable exons, are followed by downstreamC-terminal exons, or constant exons, which are shared by all genesin the cluster. The large, uninterrupted N-terminal exons eachencode six cadherin ectodomains while the C-terminal exons encodethe cytoplasmic domain. These neural cadherin-like cell adhesionproteins are integral plasma membrane proteins that most likelyplay a critical role in the establishment and function of specificcell-cell connections in the brain. Alternative splicing has beenobserved and additional variants have been suggested but theirfull-length nature has yet to be determined.