PC1/3 Antibody Summary
| Immunogen |
Synthetic peptide corresponding to residues S(111) V Q K D S A L D L F N D P M W N(127) of mouse PC1.
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| Specificity |
Prohormone Convertase 1
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
PCSK1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: Detects an approx. 80 kDa protein representing PC1 from mouse pituitary extract.
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| Publications |
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Reactivity Notes
Expected cross-reactivity with Bovine base on sequence homology.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS, 1 mg/ml BSA
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
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Alternate Names for PC1/3 Antibody
- EC 3.4.21
- EC 3.4.21.93
- NEC 1
- PC1BMIQ12
- PC3NEC1neuroendocrine convertase 1
- Prohormone convertase 1
- prohormone convertase 3
- Proprotein convertase 1
- proprotein convertase subtilisin/kexin type 1
- SPC3
Background
The subtilisin-like Prohormone Convertase (PC) family is a group of cellular enzymes that cleave most prohormones and neuropeptide precursors. Numerous other cellular proteins, some viral proteins, and bacterial toxins that are transported by the constitutive secretory pathway are also targeted for maturation by PCs. PC family members share structural similarities, which include a heterogeneous ~10 kDa amino-terminal proregion, a highly conserved ~55 kDa subtilisin-like catalytic domain, and carboxyl-terminal domain that is heterogeneous in length and sequence. These enzymes become catalytically active following proregion cleavage within the appropriate cellular compartment. The subcellular localization of PC family members varies. Immunolocalization studies show that PC1 is found in the perinuclear region as well as the trans-Golgi network, whereas PC2 can be found in the trans-Golgi network as well as diffusely distributed in the peripheral cytoplasm.