Nectin-1/PVRL1 Antibody (R1.302) Summary
| Immunogen |
NIH/3T3 cells transfected with human CD111
|
| Specificity |
The mouse monoclonal antibody R1.302 recognizes CD111 (also known as Nectin 1), a 75 kDa type I transmembrane glycoprotein broadly expressed on endothelial cells, epithelial cells, neuronal cells, megakaryocytes, and CD34-positive stem cells.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
NECTIN1
|
| Purity |
Affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Phosphate buffered saline (PBS), pH 7.4
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Affinity purified
|
Alternate Names for Nectin-1/PVRL1 Antibody (R1.302)
- CD111 antigen
- CD111
- CLPED1ectodermal dysplasia 4 (Margarita Island type)
- ED4
- Herpes virus entry mediator C
- Herpesvirus entry mediator C
- Herpesvirus Ig-like receptor
- HIgRPVRR
- HVEC
- HVECpoliovirus receptor-like 1
- MGC142031
- Nectin1
- Nectin-1
- OFC7nectin 1
- poliovirus receptor-related 1 (herpesvirus entry mediator C)
- poliovirus receptor-related protein 1
- PRR
- PRR1
- PRR1MGC16207
- PVRL1
- PVRR1
- PVRR1nectin-1
- SK-12
Background
CD111, also known as nectin-1, is a calcium-independent cell-cell adhesion transmembrane glycoprotein involved in organization of adherens junctions and tight junctions in epithelial and endothelial cells. It also serves as a target molecule for entry of herpes simplex virus (HSV-1, HSV-2) and pseudorabies virus (PRV) into epithelial and neuronal cells. CD111 is connected with actin cytoskeleton through afadin. Mutations in the gene for CD111 cause cleft lip and palate/ectodermal dysplasia 1 syndrome (CLPED1) as well as non-syndromic cleft lip with or without cleft palate (CL/P). Alternative splicing results in multiple transcript variants encoding proteins with distinct C-termini.