Nbs1 Antibody Summary
| Immunogen |
A synthetic peptide, which represented a portion of human Nijimegen breakage syndrome 1 between amino acid residues 625 and 675 encoded in part by exons 12 and 13 (LocusLink ID 4683).
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| Localization |
Nuclear
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| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
NBN
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Positive Control |
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| Publications |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Gorilla, Chimpanzee and Primates.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Nbs1 Antibody
- ATV
- AT-V1
- AT-V2
- Cell cycle regulatory protein p95
- FLJ10155
- MGC87362
- NBN
- Nbs1
- NBS1P95
- NBSNijmegen breakage syndrome protein 1
- Nibrin
- Nijmegen breakage syndrome 1 (nibrin)
- p95 protein of the MRE11/RAD50 complex
- p95
Background
The p95 gene (identical to NBS1 and nibrin) is a member of the hMre11/hRad50 double-strand break complex. This protein complex has been implicated in Nijmegen breakage syndrome, an autosomal recessive disorder marked by increased cancer incidence, cell cycle checkpoint deficits, and ionizing radiation sensitivity, thus revealing a direct molecular link between double-strand break repair and cell cycle checkpoint functions.