Product: gamma-Secretase Modulators
NRXN1 Antibody Summary
| Immunogen |
Peptide with sequence C-KEKQPSSAKSSNKN corresponding to C-Terminus according to NP_620072.1.
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| Specificity |
This antibody is expected to recognise both reported isoforms (NP_004792.1 and NP_620072.1).
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| Clonality |
Polyclonal
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| Host |
Goat
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| Gene |
NRXN1
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
WB: In transfected HEK293 transiently expressing full-length human NRXN1 (myc and DYKDDDDK tagged), bands of approx. 75 and 60 kDa band were observed. No bands were observed in mock-transfected HEK293 and the same band was observed using anti-DYKDDDDK tag antibody.
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| Positive Control |
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| Publications |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Mouse, Rat, Canine.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
0.5 mg/ml Tris (pH 7.3) and 0.5% BSA
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| Preservative |
0.02% Sodium Azide
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| Concentration |
0.5 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for NRXN1 Antibody
- DKFZp313P2036
- FLJ35941
- KIAA0578Neurexin I-alpha
- neurexin 1
- neurexin I
- Neurexin I-beta
- neurexin-1-alpha
- neurexin-1-beta
- PTHSL2
Background
Neurexins function in the vertebrate nervous system as cell adhesion molecules and receptors. Two neurexin genes are among the largest known in human (NRXN1 and NRXN3). By using alternate promoters, splice sites and exons, predictions of hundreds or even thousands of distinct mRNAs have been made. Most transcripts use the upstream promoter and encode alpha-neurexin isoforms; fewer transcripts are produced from the downstream promoter and encode beta-neurexin isoforms. Alpha-neurexins contain epidermal growth factor-like (EGF-like) sequences and laminin G domains, and they interact with neurexophilins. Beta-neurexins lack EGF-like sequences and contain fewer laminin G domains than alpha-neurexins. The RefSeq Project has decided to create only a few representative transcript variants of the multitude that are possible. [provided by RefSeq]