NMDAR1 [p Ser897] Antibody Summary
| Immunogen |
The antiserum was produced against synthesized peptide derived from human NMDAR1 around the phosphorylation site of Ser897. The immunogen region is: C-terminal.
|
| Modification |
p Ser897
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| Marker |
Neuronal Marker
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| Specificity |
NMDAR1 (Phospho-Ser897) Antibody detects endogenous levels of NMDAR1 only when phosphorylated at serine897.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
GRIN1
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for NMDAR1 [p Ser897] Antibody
- glutamate [NMDA] receptor subunit zeta-1
- glutamate receptor, ionotropic, N-methyl D-aspartate 1
- NMDA1
- NMDAR1glutamate [NMDA] receptor subunit zeta 1
- NMD-R1
- N-methyl-D-aspartate receptor channel, subunit zeta-1
- N-methyl-D-aspartate receptor subunit NR1
- NR1
Background
The ion channels activated by glutamate are typically divided into two classes. Glutamate receptors that are activated by kainate and alpha-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as kainate/AMPA receptors (K/AMPAR). Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR). The NMDAR plays an essential role in memory, neuronal development and it has also been implicated in several disorders of the central nervous system including Alzheimers, epilepsy and ischemic neuronal cell death (Grosshans et al., 2002; Wenthold et al., 2003; Carroll and Zukin, 2002). The NMDA receptor is also one of the principal molecular targets for alcohol in the CNS (Lovinger et al., 1989; Alvestad et al., 2003; Snell et al., 1996). The NMDAR is also potentiated by protein phosphorylation (Lu et al., 1999). The rat NMDAR1 (NR1) was the first subunit of the NMDAR to be cloned. The NR1 protein can form NMDA activated channels when expressed in Xenopus oocytes but the currents in such channels are much smaller than those seen in situ. Channels with more physiological characteristics are produced when the NR1 subunit is combined with one or more of the NMDAR2 (NR2 A-D) subunits.