NDRG1 Antibody (NDRG1/1383) Summary
| Immunogen |
Recombinant fragment of human NDRG1 protein
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| Localization |
Cytoplasmic and Cell Surface
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| Marker |
Marker of Tumor Aggressiveness
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| Specificity |
It recognizes a protein of 43kDa, which is identified as N-myc downstream-regulated gene 1 protein (NDRG1). The NDRG) family is comprised of four members, NDRG1, NDRG2, NDRG3 and NDRG4, which share 57-65% homology. The NDRG1 gene is ubiquitously expressed, but it is expressed most prominently in placental membranes and prostate, kidney, small intestine and ovary tissue. NDRG1 is a direct transcriptional target gene of p53 to mediated cell death and apoptosis. NDRG1 gene expression is induced by several compounds, including nickel, and produces a protein involved in stress responses, hormone responses, cell growth and differentiation. The reduced expression of NDRG1 has been found to be associated with tumor metastasis in a variety of tumors, including cancers of the breast, colon, prostate, oral cavity and oropharynx. Reportedly, overexpression of NDRG1 in hepatocellular carcinoma is an indicator of tumor aggressiveness.
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| Isotype |
IgG
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
NDRG1
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| Purity |
Protein A or G purified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Human Chromosome Location: 8q24.3
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| Theoretical MW |
43 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C.
|
| Buffer |
10mM PBS and 0.05% BSA
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| Preservative |
0.05% Sodium Azide
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| Purity |
Protein A or G purified
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Alternate Names for NDRG1 Antibody (NDRG1/1383)
- CAP43
- CMT4D
- Differentiation-related gene 1 protein
- DRG1
- DRG-1
- DRG1HMSNL
- GC4
- HMSNL
- NDR1
- NDRG1
- Nickel-specific induction protein Cap43
- NMSL
- N-myc downstream regulated 1
- N-myc downstream-regulated gene 1 protein
- protein NDRG1
- protein regulated by oxygen-1
- PROXY1
- Reducing agents and tunicamycin-responsive protein
- RIT42
- RTP
- RTPGC4
- TARG1
- TDD5
- tunicamycin-responsive protein