NCAM-1/CD56 Antibody (MEM 188) [FITC] Summary
| Immunogen |
Acute myelogenous leukemia cell line KG-1
|
| Specificity |
Human CD56
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
NCAM1
|
| Purity |
Protein A or G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
||
| Application Notes |
Additional applications reported in literature include Immunoprecipitation, Western blot, and Immunohistochemistry.
|
||
| Positive Control |
|
Reactivity Notes
Human.
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
PBS and 0.2% (w/v) high grade BSA (protease free)
|
| Preservative |
15mM Sodium Azide
|
| Purity |
Protein A or G purified
|
Alternate Names for NCAM-1/CD56 Antibody (MEM 188) [FITC]
- CD56 / NCAM-1
- CD56 antigen
- CD56
- MSK39
- NCAM1
- N-CAM-1
- NCAM-1
- NCAMantigen recognized by monoclonal 5.1H11
- neural cell adhesion molecule 1
- neural cell adhesion molecule, NCAM
Background
NCAM, as a member of the immunoglobulin superfamily of adhesion molecules is characterized by several immunoglobulin (Ig) like domains. The extracellular part of NCAM consists of five of these Ig domains and two fibronectin type III homology regions. NCAM is encoded by a single copy gene composed of 26 exons. However, at least 20-30 distinct isoforms can be generated by alternative splicing and by posttranslational modifications, such as sialylation. During sialylation, polysialic acid (PSA) carbohydrates are attached to the extracellular part of NCAM. Through its extracellular region, NCAM mediates homophilic interactions. In addition, NCAM can also undergo heterophilic interactions by binding extracellular matrix components, such as laminin, or other cell adhesion molecules, such as integrins. NCAM is expressed on most neuroectodermal derived cell lines, tissues and neoplasm such as retinoblastoma, medulloblastoma, astrocytomas and neuroblastoma.