Myosin heavy chain 2 Antibody (TH81 (BGN/04/4481)) Summary
| Immunogen |
Myosin heavy chain from rabbit muscle
|
| Localization |
Cytoplasm, myofibril. Note: thick filaments of the myofibrils.
|
| Specificity |
NB100-65675 reacts strongly with human cardiac myosin and also recognizes rabbit myosin heavy and light chains.
|
| Isotype |
IgG1
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MYH2
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.2)
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
|
Alternate Names for Myosin heavy chain 2 Antibody (TH81 (BGN/04/4481))
- fast 2a myosin heavy chain
- MYH2A
- MYHas8
- MyHC-2A
- MyHC-IIa
- MYHSA2
- myosin heavy chain 2
- myosin heavy chain 2a
- myosin heavy chain IIa
- myosin, heavy chain 2, skeletal muscle, adult
- myosin, heavy polypeptide 2, skeletal muscle, adult
- myosin-2
- skeletal muscle, adult 2
- type IIA myosin heavy chain
Background
Myosin II is the so called “classical” myosin, being the first type of myosin to be discovered. Myosin II forms bipolar filaments that interact with actin filaments to produce contraction. Myosin II was first isolated from muscle but is also found in non muscle cells, and it is especially enriched in highly motile cell types such as amoebae. The myosin II molecule is composed of two heavy chains and two sets of light chains. The light chains are the Essential Light Chains (ELC) and Regulatory Light Chains (RLC). Overall activity and polymerization can be modulated by phosphorylation on the light chains and the C terminus of the heavy chains respectively.