Mind Bomb 2/MIB2 Antibody Summary
| Immunogen |
The immunogen recognized by this antibody maps to a region between residue 925 and 975 of human mindbomb homolog 2 (Skeletrophin) using the numbering given in entry NP_543151.1 (GeneID 142678).
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| Predicted Species |
Primate (100%). Backed by our 100% Guarantee.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
MIB2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
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| Theoretical MW |
110 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
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| Publications |
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Reactivity Notes
Based on 100% sequence identity, this antibody is predicted to react with Northern white-cheeked gibbon.
Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
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| Buffer |
Tris-Citrate/Phosphate (pH 7.0 – 8.0)
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| Preservative |
0.09% Sodium Azide
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| Concentration |
1.0 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Mind Bomb 2/MIB2 Antibody
- E3 ubiquitin-protein ligase MIB2
- EC 6.3.2
- EC 6.3.2.-
- EC 6.3.2.13
- FLJ20648
- FLJ41406
- MIB2
- Mind Bomb 2
- Mind bomb homolog 2
- Mind Bomb-2
- mindbomb homolog 2 (Drosophila)
- Novel zinc finger protein
- Novelzin
- Putative NF-kappa-B-activating protein 002N
- SKD
- Skeletrophin
- Zinc finger ZZ type with ankyrin repeat domain protein 1
- ZZ type with ankyrin repeat domain 1
- ZZANK1
- ZZZ5
Background
MIB2/Skeletrophin is an actin-binding protein that bears two MIB/HERC2 domains, a ZZ-type zinc-finger domain, nine ankyrin repeats, and two RING-finger domains. The C-terminal RING domain has been found to have E3 ubiquitin ligase activity that mediates ubiquitination of the intracellular regions of the Notch receptor and its ligands to regulate Notch signaling. MIB2/Skeletrophin appears to be important to muscle development and may function as a suppressor of melanoma invasion.