Melanocortin-1 R/MC1R Antibody

Product: Microcystin-LR

Melanocortin-1 R/MC1R Antibody Summary

Immunogen
Synthetic 16 amino acid peptide from 3rd cytoplasmic domain of human MC1 Receptor.
Epitope
3rd cytoplasmic domain of human
Specificity
Human MC1 Receptor. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
Clonality
Polyclonal
Host
Rabbit
Gene
MC1R
Purity
Immunogen affinity purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin assay dependent

Reactivity Notes

Chimpanzee, Gorilla, Orangutan, Gibbon, Monkey (100%); Baboon, Cat, Panda (94%).

Packaging, Storage & Formulations

Storage
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Buffer
PBS
Preservative
0.1% Sodium Azide
Concentration
1.0 mg/ml
Purity
Immunogen affinity purified

Alternate Names for Melanocortin-1 R/MC1R Antibody

  • CMM5
  • MC1R
  • MC1-R
  • melanocortin 1 receptor (alpha melanocyte stimulating hormone receptor)
  • Melanocortin receptor 1
  • Melanocortin-1 R
  • Melanocortin1R
  • Melanocortin-1R
  • melanocyte-stimulating hormone receptor
  • melanotropin receptor
  • MSHR
  • MSH-R
  • Mshra
  • MSH-RMGC14337
  • SHEP2
  • Tob

Background

MC1R, a Melanocortin Receptor, mediates the effects of melanocyte-stimulating hormone (MSH) and adrenocorticotropic hormone (ACTH). MSH and its receptor, MC1R, are key regulators of melanogenesis. They control the relative proportions of red pheomelanin and black photoprotective eumelanin in the skin by increasing the production of eumelanin. Non-functional, truncated forms of the receptor lead to lighter coat color in animals. In contrast, constitutively active receptors lead to darker color. Pheomelanin generates free radicals in response to UV radiation, and elevated levels of pheomelanin have been associated with higher risk of UV-induced skin damage. Therefore, MC1R is a major determinant of sun sensitivity and genetic risk for melanoma and other skin cancers. Expression of melanocortin 1 receptor has been reported primarily in adrenal, skin, and testis. ESTs have been isolated from breast, placenta, and testis libraries.

PMID: 11906291