Product: NAN-190 (hydrobromide)
Mcl-1 Antibody Summary
| Immunogen |
Synthetic peptide derived from the sequence of human Mcl-1, conjugated to KLH
|
| Specificity |
Mcl-1
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
MCL1
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
This antibody is useful for Immunofluorescence, Immunohistochemistry, Western blot.
|
Reactivity Notes
Human, Canine, Guinea Pig, Monkey, Pig, Rabbit.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
No buffer
|
| Preservative |
Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Mcl-1 Antibody
- BCL2L3
- bcl2-L-3
- BCL2L3MGC104264
- Bcl-2-like protein 3
- Bcl-2-related protein EAT/mcl1
- EAT
- induced myeloid leukemia cell differentiation protein Mcl-1
- Mcl1
- Mcl-1
- mcl1/EAT
- MCL1-ES
- MCL1L
- MCL1S
- MGC1839
- myeloid cell leukemia ES
- myeloid cell leukemia sequence 1 (BCL2-related)
- TM
Background
Mcl1 is an anti-apoptotic member of Bcl2 family originally isolated from the ML1 human myeloid leukemia cell line during phorbol ester-induced differentiation along the monocyte/macrophage pathway. Mcl1 localizes to the mitochondria, interacts with and antagonizes pro-apoptotic Bcl2 family members, and inhibits apoptosis by a number of cytotoxic stimuli. It is involved in programing of differentiation and concomitant maintenance of viability but not of proliferation. Isoform 1 inhibits apoptosis while isoform 2 promotes it. Expression increases early during phorbol-ester induced differentiation along the monocyte/macrophage pathway in myeloid leukemia cell lines ML1.