MSC 2032964A Inhibitor Summary
Description |
Biological Activity
Potent and selective ASK1 inhibitor (IC50 = 93 nM). Selective for ASK1 over a panel of 210 kinases. Blocks LPS-induced ASK1 and p38 phosphorylation in cultured mouse astrocytes. Suppresses neuroinflammation in a mouse EAE model. Orally bioavailable and brain penetrant. Technical Data |
Packaging, Storage & Formulations
Storage |
Store at -20 °C.
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