Product: Benzenepentacarboxylic Acid
MMP-9 Antibody (S51-82) Summary
| Immunogen |
Fusion protein amino acids 1-708 (full length) of rat MMP9
|
| Localization |
Extracellular Matrix
|
| Specificity |
Detecs ~92kDa and ~82kDa (pro and active forms).
|
| Isotype |
IgG2a
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MMP9
|
| Purity |
Protein G purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
1 ug/ml of this antibody was sufficient for detection of MMP9 in 20 ug of COS-1 cells (lysate) transfected with human MMP9 by colorimetric immunoblot analysis using goat anti-mouse IgG:HRP as the secondary antibody.
|
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS pH7.4, 50% glycerol
|
| Preservative |
0.09% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for MMP-9 Antibody (S51-82)
- 92 kDa gelatinase
- 92 kDa type IV collagenase
- CLG4B
- EC 3.4.24
- EC 3.4.24.35
- Gelatinase B
- GELB
- macrophage gelatinase
- MANDP2
- matrix metallopeptidase 9
- matrix metalloproteinase 9
- matrix metalloproteinase-9
- MMP9
- MMP-9
- type V collagenase
Background
MMP9, otherwise known as matrix metalloproteinase 9, is involved in the breakdown of extracellular matrix in normal physiological processes such as embryonic development, reproduction and tissue remodeling, as well as in disease processes like arthritis and metastasis (1). Among the family members, MMP-2, MMP-3, MMP-7 and MMP-9 have been characterized as important factors for normal tissue remodeling during embryonic development, wound healing, tumor invasion, angiogenesis, carcinogenesis and apoptosis (2-4). MMP activity correlates with cancer development (2). One mechanism of MMP regulation is transcriptional (5). Once synthesized, MMP exists as a latent proenzyme. Maximum MMP activity requires proteolytic cleavage to generate active MMPs by releasing the inhibitory propeptide domain from the full length protein (5).