MKK7/MEK7 Antibody (4D2) Summary
| Immunogen |
MAP2K7 (NP_660186, 1 a.a. – 99 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. MAASSLEQKLSRLEAKLKQENREARRRIDLNLDISPQRPRPTLQLPLANDGGSRSPSSESSPQHPTPPARPRHMLGLPSTLFTPRSMESIEIDQKLQEI
|
| Localization |
Cytoplasmic and Nuclear
|
| Specificity |
MAP2K7 – mitogen-activated protein kinase kinase 7
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MAP2K7
|
| Purity |
IgG purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for ELISA.
|
Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for MKK7/MEK7 Antibody (4D2)
- c-Jun N-terminal kinase kinase 2
- dual specificity mitogen-activated protein kinase kinase 7
- EC 2.7.12.2
- JNK kinase 2
- JNK-activating kinase 2
- JNKK 2
- JNKK2
- MAP kinase kinase 7
- MAP2K7
- MAPK/ERK kinase 7
- MAPKK7
- MEK 7
- MEK7
- mitogen-activated protein kinase kinase 7
- MKE7
- MKK7
- MKK7MAPKK 7
- PRKMK7
Background
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase specifically activates MAPK8/JNK1 and MAPK9/JNK2, and this kinase itself is phosphorylated and activated by MAP kinase kinase kinases including MAP3K1/MEKK1, MAP3K2/MEKK2,MAP3K3/MEKK5, and MAP4K2/GCK. This kinase is involved in the signal transduction mediating the cell responses to proinflammatory cytokines, and environmental stresses. Multiple alternatively spliced transcript variants encoding distinct isoforms have been found, but only one transcript variant has been supported and defined.