MKK4/MEK4 Antibody (323042) Summary
| Immunogen |
E. coli-derived recombinant human MKK4
Met1-Asp399 Accession # P45985 |
| Specificity |
Detects human MKK4 in direct ELISAs. This antibody does not cross-react with recombinant human MKK7.
|
| Source |
N/A
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MAP2K4
|
| Purity |
Protein A or G purified from hybridoma culture supernatant
|
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Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Use a manual defrost freezer and avoid repeated freeze-thaw cycles.
|
| Buffer |
Lyophilized from a 0.2 μm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied as a 0.2 µm filtered solution in PBS.
|
| Preservative |
No Preservative
|
| Concentration |
LYOPH
|
| Purity |
Protein A or G purified from hybridoma culture supernatant
|
| Reconstitution Instructions |
Reconstitute at 0.5 mg/mL in sterile PBS.
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Notes
This product is produced by and ships from R&D Systems, Inc., a Bio-Techne brand.
Alternate Names for MKK4/MEK4 Antibody (323042)
- c-Jun N-terminal kinase kinase 1
- dual specificity mitogen-activated protein kinase kinase 4
- JNK activating kinase 1
- JNK-activated kinase 1
- JNK-activating kinase 1
- JNKK
- JNKK1
- JNKK1MAPK/ERK kinase 4
- MAP kinase kinase 4
- MAP2K4
- MAPKK4
- MEK4
- MEK4MEK 4
- mitogen-activated protein kinase kinase 4
- MKK4
- MKK4SAPK/ERK kinase 1
- PRKMK4
- PRKMK4MAPKK 4
- SEK1
- SERK1
- SERK1EC 2.7.12.2
Background
MKK4, also known as MEK4, JNKK1, SEK1, MAP2K4, is an intracellular protein kinase that functions in the JNK (Jun N-terminal kinase) signal transduction pathway. In response to activation by one of several MAPKKKs, MKK4 (and MKK7) phosphorylates and activates the JNKs that regulate neural development, apoptosis, inflammation, and cellular responses to stress.