MEK5 [p Ser311, p Thr315] Antibody Summary
| Immunogen |
Phosphopeptide corresponding to amino acid residues surrounding the phosphoSer311, Thr315 of MEK5.
|
| Modification |
p Ser311, p Thr315
|
| Specificity |
Specific for the approx. 49k MEK5 protein phosphorylated at Ser311, Thr314. Immunolabeling of the MEK5 band is blocked by preadsorption with the phospho-peptide used as antigen but not be the corresponding dephospho-peptide.
|
| Predicted Species |
Human (100%), Mouse (100%), Bovine (100%), Chicken (100%), Zebrafish (100%), Primate (100%), Xenopus (100%), Canine (100%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
MAP2K5
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
49 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
10mM HEPES (pH 7.5), 0.15M NaCl, 0.1 mg/ml BSA and 50% Glycerol
|
| Preservative |
No Preservative
|
| Concentration |
0.35 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for MEK5 [p Ser311, p Thr315] Antibody
- HsT17454
- MAP kinase kinase 5
- MAP kinase kinase MEK5b
- MAP2K5
- MAPK/ERK kinase 5
- MAPKK 5
- MAPKK5
- MAPKK5EC 2.7.12.2
- MEK5
- MEK5MEK 5
- mitogen-activated protein kinase kinase 5
- MKK5
- PRKMK5
- PRKMK5dual specificity mitogen-activated protein kinase kinase 5
Background
MEK5 (also known as MKK5) is a dual specificity serine/threonine protein kinase belonging to the MAP kinase kinase family. MEK5 has been shown to specifically activate ERK5 (Zhou et al., 1995) whereas MEK5 itself is regulated by MEKK3 (Chao et al., 1999). An important link between MEK5 and metastatic prostrate cancer has been demonstrated (Mehta et.al., 2003). Dual phosphorylation of Ser311 and Thr315 have been implicated in cell proliferation (Cameron et al., 2004).