MALT1 Antibody (SPM578) – IHC-Prediluted

Product: Xanomeline (oxalate)

MALT1 Antibody (SPM578) – IHC-Prediluted Summary

Immunogen
Human MALT1 recombinant fragment (aa701-808)
Localization
Cytoplasmic
Marker
MALT-Lymphoma Marker
Specificity
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
Isotype
IgG1 Kappa
Clonality
Monoclonal
Host
Mouse
Gene
MALT1
Purity
Protein A or G purified
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Applications/Dilutions

Dilutions
  • Immunohistochemistry-Paraffin
Application Notes
Hu-chromosome location: 18q21.32
Immunohistochemistry-Paraffin 0.5 – 1 ug/ml for 30 minutes at RT; Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10 – 20 min followed by cooling at RT for 20 minutes. The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.
Theoretical MW
93 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors.

Packaging, Storage & Formulations

Storage
Store at 4C.
Buffer
10mM PBS and 0.05% BSA
Preservative
0.05% Sodium Azide
Purity
Protein A or G purified

Alternate Names for MALT1 Antibody (SPM578) – IHC-Prediluted

  • caspase-like protein
  • DKFZp434L132
  • EC 3.4.22.-
  • MALT associated translocation
  • MALT lymphoma-associated translocation
  • MALT1
  • MLT1
  • MLTMALT-lymphoma associated translocation
  • mucosa associated lymphoid tissue lymphoma translocation gene 1
  • mucosa-associated lymphoid tissue lymphoma translocation protein 1
  • Paracaspase

PMID: 15555631