MALT1 Antibody (SPM578) [Allophycocyanin] Summary
| Immunogen |
Human MALT1 recombinant fragment (aa701-808)
|
| Localization |
Cytoplasmic
|
| Marker |
MALT-Lymphoma Marker
|
| Specificity |
Mucosa associated lymphoid tissue lymphoma translocation gene 1 (MALT1) is found in extranodal low-grade B cell lymphomas. MALT1 encodes two Ig-like C2-type domains and fuses with an API2 gene, which is highly expressed in adult lymphoid tissue. The translocation of this MALT1 gene, which maps to human chromosome 18q21, and the apoptosis-inhibiting API2 gene results in an increased development of MALT lymphomas and apoptosis inhibition. Sites at which this API2-MALT1 (11;18)(q21;q21) translocation commonly occurs are within human lung and kidney tissue. MALT lymphoma expresses nuclear Bcl10, which mediates the oligomerization and activation of a MALT1 caspase-like domain. MALT1 mRNA is found in pre-B cells, mature B cells and plasma cells.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MALT1
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
|
| Theoretical MW |
93 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for MALT1 Antibody (SPM578) [Allophycocyanin]
- caspase-like protein
- DKFZp434L132
- EC 3.4.22.-
- MALT associated translocation
- MALT lymphoma-associated translocation
- MALT1
- MLT1
- MLTMALT-lymphoma associated translocation
- mucosa associated lymphoid tissue lymphoma translocation gene 1
- mucosa-associated lymphoid tissue lymphoma translocation protein 1
- Paracaspase