Lyp/PTPN22 Antibody (4F6) Summary
| Immunogen |
PTPN22 (AAH17785, 1 a.a. ~ 180 a.a) full length recombinant protein with GST tag.MDQREILQKFLDEAQSKKITKEEFANEFLKLKRQSTKYKADKTYPTTVAEKPKNIKKNRYKDILPYDYSRVELSLITSDEDSSYINANFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYSVLIIVMACMEYEMGKEAEKRKSDYIIRTLKVKFNSVSVILAHQTSLQNLFSQITPAHF
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| Specificity |
PTPN22 (4F6)
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| Isotype |
IgG2a Kappa
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
PTPN22
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| Purity |
IgG purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Antibody reactive against recombinant protein for western blot. It has also been used for RNAi validaton and ELISA.
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| Publications |
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Reactivity Notes
This antibody was tested in transfected lysates of mouse origin in PMID: 23619366. However, we have had mixed results with detection of the mouse protein in western blot.
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
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| Buffer |
PBS (pH 7.4)
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| Preservative |
No Preservative
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| Purity |
IgG purified
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Notes
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for Lyp/PTPN22 Antibody (4F6)
- EC 3.1.3.48
- Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP
- Lymphoid phosphatase
- lymphoid-specific protein tyrosine phosphatase
- Lyp
- Lyp1
- Lyp2
- LyPTP
- PEP
- PEST-domain phosphatase
- protein tyrosine phosphatase, non-receptor type 22 (lymphoid)
- protein tyrosine phosphatase, non-receptor type 8
- PTPN22
- PTPN8 (former)
- PTPN8LYP1
- tyrosine-protein phosphatase non-receptor type 22
Background
This gene encodes a protein tyrosine phosphatase which is expressed primarily in lymphoid tissues. This enzyme associates with the molecular adapter protein CBL and may be involved in regulating CBL function in the T-cell receptor signaling pathway. Alternative splicing of this gene results in two transcript variants encoding distinct isoforms.