Latrophilin 2/LPHN2 Antibody Summary
| Immunogen |
Synthetic 16 amino acid peptide from N-terminal extracellular domain of human LPHN2.
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| Localization |
Integral membrane protein.
|
| Specificity |
Human LPHN2. BLAST analysis of the peptide immunogen showed no homology with other human proteins.
|
| Predicted Species |
Opossum (100%), Xenopus (94%), Fish (94%), Chicken (94%), Primate (94%). Backed by our 100% Guarantee.
|
| Clonality |
Polyclonal
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| Host |
Rabbit
|
| Gene |
LPHN2
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Reactivity Notes
Predicted cross-reactivity based on sequence identity: Gorilla (100%), Gibbon (100%), Elephant (100%), Panda (100%), Platypus (100%), Marmoset (94%), Pufferfish (94%).
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.1% Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Latrophilin 2/LPHN2 Antibody
- Calcium-independent alpha-latrotoxin receptor 2
- CIRL2
- CIRL-2
- CL2
- KIAA0786
- Latrophilin 2
- Latrophilin homolog 1
- latrophilin homolog 2 (cow)
- latrophilin-2
- LEC1LPHH1latrophilin 1
- lectomedin-1
- LPHN2
Background
LPHN2 is an Orphan-B Receptor that binds alpha-latrotoxin, a potent presynaptic neurotoxin present in the venom of the black widow spider, in a Ca2+-independent manner. As with the other two latrophilins, it shares homology with lectin, olfactomedin, and transmembrane domains, and possesses variable C-termini and various alternative-splice sites. LPHN2 is endoproteolytically cleaved at the end of the GPS domain, and the two subunits remain non-covantely linked as a heterodimer. LPHN2 has been reported to be expressed in brain, breast, placenta, kidney, spleen, ovary, heart, and lung. ESTs have been isolated from a wide variety of tissue libraries.