Lass5 Antibody Summary
| Immunogen |
Antibody was raised against a 17 amino acid synthetic peptide near the carboxy terminus of the human LASS5. The immunogen is located within the last 50 amino acids of LASS5.
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| Specificity |
Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
CERS5
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
LASS5 antibody can be used for detection of LASS5 by Western blot at 1 – 2 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Lass5 Antibody
- CerS5
- FLJ25304
- LAG1 homolog, ceramide synthase 5
- LAG1 longevity assurance homolog 5 (S. cerevisiae)
- LAG1 longevity assurance homolog 5
- MGC45411
- Trh4
Background
The LASS (longevity assurance homolog) family members represent a subgroup of the homeobox gene family and are highly conserved from yeasts to mammals. Six members of this family of proteins have been characterized (LASS1-6) and all are involved in ceramide synthesis during cell growth regulation and cancer differentiation. LASS5, also called Trh4, is a 392 amino acid endoplasmic reticulum, multi-pass membrane protein. Functioning as a dihydro-ceramide synthase, LASS5 is involved in the production of sphingolipids containing mainly one fatty acid donor (N-linked palmitoyl-ceramide) in a fumonisin B1-independent manner. It uses palmitoyl-CoA as an acyl donor and is involved in the synthesis of C14, C16 and C18-ceramide. LASS5 is the most abundantly expressed and predominant ceramide synthase isoform in lung epithelia. Recent studies show that LASS5 partially correct growth and apoptosis. Multiple isoforms of LASS5 are known to exist. This antibody may cross-react with the highly homologous LASS6.