L-Selectin/CD62L Antibody (FMC46) [Alexa Fluor® 647] Summary
| Immunogen |
PHA stimulated lymphoblasts.
|
| Localization |
Membrane; single pass type I membrane protein.
|
| Specificity |
NB100-65388 recognizes human CD62L, also known a L-selectin, a 74-95kDa member of the selectin family of adhesion receptors, which acts as a ligand for both CD62-P (P-selectin) and CD62E (E-selectin). Human CD62L is constitutively expressed on most leucocytes including monocytes, granulocytes, lymphocytes, NK cells, bone marrow myeloid progenitor cells and on a subset of thymocytes. CD62L plays an important role in leucocyte tethering and rolling on the endothelial cell surface and for the homing of naive lymphocytes to lymph nodes and Peyers patches via HEV. Neutrophils require a constant supply of this molecule on the cell surface for migration into peripheral tissues and adhesion to activated endothelium at sites of inflammation, where CD62L is rapidly shed as soluble L-selectin, but surface expression still remains. The expression of CD62L is down regulated on lymphocytes and neutrophils by PMA stimulation.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
SELL
|
| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein G purified
|
Notes
This product is provided under an intellectual property license from Life Technologies Corporation. The purchase of this product conveys to the buyer the non-transferable right to use the purchased product and components of the product only in research conducted by the buyer (whether the buyer is an academic or for-profit entity). The sale of this product is expressly conditioned on the buyer not using the product or its components, or any materials made using the product or its components, in any activity to generate revenue, which may include, but is not limited to use of the product or its components: (i) in manufacturing; (ii) to provide a service, information, or data in return for payment; (iii) for therapeutic, diagnostic or prophylactic purposes; or (iv) for resale, regardless of whether they are resold for use in research. For information on purchasing a license to this product for purposes other than as described above, contact Life Technologies Corporation, 5791 Van Allen Way, Carlsbad, CA 92008 USA or [email protected].
Alternate Names for L-Selectin/CD62L Antibody (FMC46) [Alexa Fluor® 647]
- CD62L antigen
- CD62L
- gp90-MEL
- hLHRc
- LAM1
- LAM-1
- LAM1LECAM1
- LECAM1
- LEU8
- Leu-8
- Leukocyte adhesion molecule 1
- Leukocyte surface antigen Leu-8
- Leukocyte-endothelial cell adhesion molecule 1
- LNHR
- LNHRTQ1
- LSEL
- L-Selectin
- LYAM1
- Lyam-1
- LYAM1CD62 antigen-like family member L
- Lymph node homing receptor
- lymphocyte adhesion molecule 1
- pln homing receptor
- PLNHR
- selectin L
- SELL
- TQ1