LMP7/PSMB8 Antibody Summary
| Immunogen |
Synthetic Peptide: C V(259) E S T D V S D L L H Q Y R E A(274)
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
PSMB8
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
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| Publications |
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Reactivity Notes
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS, with 1 mg/ml
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for LMP7/PSMB8 Antibody
- ALDD
- beta5i
- D6S216E
- EC 3.4.25.1
- JMP
- LMP7
- LMP7MGC1491
- Low molecular mass protein 7
- low molecular weight protein 7
- Macropain subunit C13
- Multicatalytic endopeptidase complex subunit C13
- NKJO
- protease component C13
- proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctionalpeptidase 7)
- proteasome catalytic subunit 3i
- Proteasome Component C13
- proteasome subunit beta 5i
- proteasome subunit beta type-8
- Proteasome subunit beta-5i
- Proteasome Subunit Y2
- proteasome-related gene 7
- PSMB5i
- PSMB5iD6S216
- PSMB8
- Really interesting new gene 10 protein
- RING10
- RING10proteasome (prosome, macropain) subunit, beta type, 8 (large multifunctionalprotease 7)
- Y2
Background
The 26S proteasome is an ATP-dependent, multisubunit (~31), barrel-shaped molecular machine with an apparent molecular weight of ~2.5 MDa. It consists of a 20S proteolytic core complex which is crowned at one or both ends by 19S regulatory subunit complexes. The 19S regulatory subunits recognize ubiquitinated proteins and play an essential role in unfolding and translocating targets into the lumen of the 20S subunit. An enzymatic cascade is responsible for the attachment of multiple ubiquitin molecules to lysine residues of proteins targeted for degradation. Several genetic diseases are associated with defects in the ubiquitin-proteasome pathway. Some examples of affected proteins include those linked to cystic fibrosis, Angelmans syndrome, and Liddle syndrome.