LIM Kinase 1/2 [p Thr508, p Thr505] Antibody Summary
| Immunogen |
KLH-conjugated synthetic peptide encompassing a sequence within the C-term region of human LIMK1/2
|
| Modification |
p Thr505, p Thr508
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
LIMK1
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
Liquid in 0.42% Potassium phosphate; 0.87% Sodium chloride, and 30% glycerol; pH 7.3;
|
| Preservative |
0.01% Sodium Azide
|
| Purity |
Immunogen affinity purified
|
Alternate Names for LIM Kinase 1/2 [p Thr508, p Thr505] Antibody
- EC 2.7.11.1
- LIM domain kinase 1
- LIM motif-containing protein kinase
- LIMKLIMK-1
Background
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase 1 and LIM kinase 2 belong to a small subfamily with a unique combination of 2 N terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is likely to be a component of an intracellular signaling pathway and may be involved in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Two splice variant have been identified.