LAMP-2/CD107b Antibody Summary
| Immunogen |
Antibody was raised against a 17 amino acid synthetic peptide from near the carboxy terminus of human LAMP-2. The immunogen is located within the last 50 amino acids of LAMP-2.
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| Marker |
Late Endosome / Lysosome marker
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| Specificity |
LAMP-2 antibody cross reacts with LAMP2B and LAMP2C, but not LAMP2A.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
LAMP2
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
LAMP-2 antibody can be used for the detection of LAMP-2 by Western blot at 1 – 2 mg/ml.
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| Control Peptide |
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Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
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| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for LAMP-2/CD107b Antibody
- CD107 antigen-like family member B
- CD107b antigen
- CD107b
- LAMP2
- LAMP-2
- LAMPB
- LGP110
- lysosomal-associated membrane protein 2
- lysosome-associated membrane glycoprotein 2
- Lysosome-associated membrane protein 2
Background
Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components and is negatively regulated by TOR (Target of rapamycin). LAMP-2, a highly glycosylated protein associated with the lysosome, has recently been shown to be important in autophagy as mice deficient in this protein failed to convert autophagic vacuoles into vacuoles leading to impaired degradation of long-lived proteins. This correlates with the finding that human LAMP-2 deficiency causing Danons disease is associated with the accumulation of autophagic material in striated myocytes. LAMP-2 exists in multiple isoforms.