Ku80/XRCC5 Antibody Summary
| Immunogen |
A synthetic peptide corresponding to residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein.
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| Specificity |
Reacts with residues 323-338 [FSKVDEEQMKYKSEGK] of the 80 kDa Ku80 protein. Sequence is 100% conserved between human, mouse and rat.
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
XRCC5
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| Purity |
Immunogen affinity purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
This antibody has only been tested in Western blot. Recommended working dilution: WB at 1:500 dilution However, the investigator should determine the optimal dilution.
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Reactivity Notes
This antibody reacts with human, rat, and mouse.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
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| Preservative |
0.02% Sodium Azide
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| Concentration |
1 mg/ml
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| Purity |
Immunogen affinity purified
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Alternate Names for Ku80/XRCC5 Antibody
- 80kDa
- ATP-dependent DNA helicase 2 subunit 2
- ATP-dependent DNA helicase II 80 kDa subunit
- CTC85
- CTCBF
- EC 3.6.4.-
- FLJ39089
- G22P2
- KARP1
- KARP-1
- Ku80
- Ku86 autoantigen related protein 1,86 kDa subunit of Ku antigen
- Ku86
- Ku86DNA repair protein XRCC5
- KUB2
- NFIV
- Thyroid-lupus autoantigen
- TLAA
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining)CTC box-binding factor 85 kDa subunit
- X-ray repair complementing defective repair in Chinese hamster cells 5(double-strand-break rejoining; Ku autoantigen, 80kD)
- X-ray repair cross-complementing protein 5
- X-ray repair, complementing defective, repair in Chinese hamster
- XRCC5
Background
Telomere length maintenance, an activity essential for chromosome stability and genome integrity, is regulated by telomerase- and telomere-associated factors. The DNA repair protein Ku (a heterodimer of Ku70 and Ku80 subunits) associates with mammalian telomeres and contributes to telomere maintenance. The Ku heterodimer functions at two kinds of DNA ends: telomeres and double-strand breaks. The role that Ku plays at these two classes of termini must be distinct, because Ku is required for accurate and efficient joining of double-strand breaks while similar DNA repair events are normally prohibited at chromosome ends.