Ku70/XRCC6 Antibody (KU729) [Biotin] Summary
| Immunogen |
Nuclear extract of human HL-60 cells
|
| Localization |
Nuclear
|
| Marker |
Nuclear Marker
|
| Specificity |
Recognizes a dimer of two proteins of 70kDa and ~80kDa, identified as two subunits of Ku. This MAb recognizes a conformational epitope of p70/p80 dimer, which is destroyed during Western blotting. The p70/p80 dimer is important for function of a 460kDa DNA-dependent protein kinase. Ku protein plays a role in cell signaling, proliferation, DNA repair, replication, transcriptional activation, and apoptosis.
|
| Isotype |
IgG1 Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
XRCC6
|
| Purity |
Protein A purified
|
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Immunohistochemistry (Staining of formalin-fixed tissues requires boiling tissue sections in 10mM Citrate Buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes)
|
| Theoretical MW |
75 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
| Readout System |
|
Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Purity |
Protein A purified
|
Alternate Names for Ku70/XRCC6 Antibody (KU729) [Biotin]
- 5-deoxyribose-5-phosphate lyase Ku70
- 5-dRP lyase Ku70
- 70 kDa subunit of Ku antigen
- ATP-dependent DNA helicase 2 subunit 1
- ATP-dependent DNA helicase II 70 kDa subunit
- CTC box binding factor 75 kDa subunit
- CTC box-binding factor 75 kDa subunit
- CTC75
- CTCBF
- D22S731
- EC 3.6.4.-
- EC 4.2.99.-
- G22P1
- G22P1Ku70
- Ku autoantigen p70 subunit
- Ku autoantigen, 70kDa
- Ku70
- ML8
- ML8,70 kDa subunit
- thyroid-lupus autoantigen p70
- Thyroid-lupus autoantigen
- TLAA
- TLAAD22S671
- X-ray repair complementing defective repair in Chinese hamster cells 6DNA repair protein XRCC6
- X-ray repair cross-complementing protein 6
- XRCC6