Kinesin Antibody Summary
| Immunogen |
Stalk domain of human kinesin (amino acids 331-906) expressed in E. coli (FKHC3).
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| Specificity |
This detects total level of endogenous kinesin protein
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
KIF5B
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| Purity |
Protein A purified
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Predicted molecular weight: 110 kDa. Purity is > 95% (by SDS-PAGE)
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Packaging, Storage & Formulations
| Storage |
Store at 4C. Do not freeze.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
15mM Sodium Azide
|
| Concentration |
1.0 mg/ml
|
| Purity |
Protein A purified
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Alternate Names for Kinesin Antibody
- Conventional kinesin heavy chain
- kinesin family member 5B
- kinesin-1 heavy chain
- KNS1kinesin 1 (110-120kD)
- KNSKINH
- Ubiquitous kinesin heavy chain
- UKHCkinesin heavy chain
Background
Kinesin belongs to the group of motor proteins known to convert chemical energy released from ATP into mechanical energy. Conventional kinesin, member of the kinesin superfamily comprising more than 100 proteins, is involved in the anterograde vesicle transport inneuronal cells. Kinesin purified from mammalian brain homogenates is a heterotetramer consisting of two heavy (120 to 130 kDa) and two light chains (60 to 70 kDa), resulting in a molecular mass about 400 kDa. Each heavy chain contains an N terminal globular motordomain with both a microtubule binding site and an ATPase active center, stalk region responsible for heavy chain dimerization and finally C terminal globular tail domain, which is implicated in cargo binding. Light chains may have a regulatory function.