Product: Pralidoxime (chloride)
Kinesin 5A Antibody Summary
| Immunogen |
Synthetic Peptide: C(1007) G Y E A E D Q A K L F P L H Q E T A A S(1027)
|
| Localization |
Concentrated in the cell body of the neurons, particularly in the perinuclear region.
|
| Specificity |
This is specific for kinesin 5A and does not detect other kinesin isotypes.
|
| Isotype |
IgG
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
KIF5A
|
| Purity |
Immunogen affinity purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
WB: Detects an approx. 110 kDa (predicted molecular weight: 117 kDa) representing kinesin 5A from mouse neuronal cell lysate and human retinal extracts.
|
Reactivity Notes
Expected cross-reactivity with Rat (95%) base on sequence homology.
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS
|
| Preservative |
0.05% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Kinesin 5A Antibody
- D12S1889
- KIF5A variant protein
- kinesin family member 5A
- kinesin heavy chain isoform 5A
- Kinesin heavy chain neuron-specific 1
- kinesin, heavy chain, neuron-specific
- MY050
- Neuronal kinesin heavy chain
- NKHC1
- NKHCspastic paraplegia 10 (autosomal dominant)
- SPG10
Background
Kinesins are a superfamily of microtubule-associated motor proteins involved in a variety of cellular processes including membranous organelle transport and cell division. Kinesin has been found in a variety of organisms and cell types and is subject to spatial and temporal regulation. These proteins have a modular structure including a conserved motor domain of approximately 350 amino acids, which is responsible for microtubule binding and ATP hydrolysis. In addition to the motor domain, subfamily members share common domain organization, exhibit sequence similarity, motility properties, and cellular functions outside of the motor domain. There are currently three known Kinesin 5 family members denoted as A, B, and C. Kinesin 5A and kinesin 5C appear to be exclusively neuronal, whereas kinesin 5B appears to be ubiquitous in its expression.