JNK3 Antibody (10E4A4) Summary
| Immunogen |
Purified recombinant fragment of human MAPK10 (aa28-233) expressed in E. Coli.
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| Isotype |
IgG1
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| Clonality |
Monoclonal
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| Host |
Mouse
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| Gene |
MAPK10
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| Purity |
Unpurified
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| Innovators Reward |
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Applications/Dilutions
| Dilutions |
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Reactivity Notes
Human, Mouse. Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
Ascites
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| Preservative |
0.03% Sodium Azide
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| Purity |
Unpurified
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Alternate Names for JNK3 Antibody (10E4A4)
- c-Jun N-terminal kinase 3
- EC 2.7.11
- EC 2.7.11.24
- JNK3 alpha protein kinase
- JNK3
- JNK3A
- JNK3FLJ12099
- MAP kinase 10
- MAP kinase p49 3F12
- MAPK 10
- MAPK10
- MGC50974
- mitogen-activated protein kinase 10
- p493F12
- p54bSAPK
- PRKM10FLJ33785
- SAPK1 beta
- stress activated protein kinase beta
- Stress-activated protein kinase JNK3
Background
C-Jun N-terminal kinases (JNK) are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group consists of three isoforms (JNK1, 2, and 3) and regulates transcription activity of the AP-1 complex, and release and regulation of cytochome c (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). Unlike other JNK isoforms, JNK3 is only expressed in heart and nervous system nervous. JNK3 has been implicated in stress-induced neuronal apoptosis (3).