JNK2 Antibody (3C12) Summary
| Immunogen |
MAPK9 (AAH32539 321 a.a. – 424 a.a.) partial recombinant protein with GST tag. MW of the GST tag alone is 26 KDa. ITVWYDPAEAEAPPPQIYDAQLEEREHAIEEWKELIYKEVMDWEERSKNGVVKDQPSDAAVSSNATPSQSSSINDISSMSTEQTLASDTDSSLDASTGPLEGCR
|
| Localization |
Nuclear
|
| Specificity |
MAPK9 – mitogen-activated protein kinase 9
|
| Isotype |
IgG2a Kappa
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
MAPK9
|
| Purity |
IgG purified
|
| Innovators Reward |
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|
Applications/Dilutions
| Dilutions |
|
| Application Notes |
Antibody reactivity against cell lysate and recombinant protein for WB. It has also been used for IF and ELISA.
|
Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Purity |
IgG purified
|
Notes
Quality control test: Antibody Reactive Against Recombinant Protein.
This product is produced by and distributed for Abnova, a company based in Taiwan.
Alternate Names for JNK2 Antibody (3C12)
- c-Jun kinase 2
- c-Jun N-terminal kinase 2
- EC 2.7.11
- EC 2.7.11.24
- JNK2
- JNK2A
- JNK2BETA
- JNK2JNK2ALPHA
- JNK-55
- Jun kinase
- MAP kinase 9
- MAPK 9
- MAPK9
- mitogen-activated protein kinase 9
- p54a
- p54aSAPK
- PRKM9JNK2B
- SAPK
- SAPK1 alpha
- Stress-activated protein kinase JNK2
Background
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase targets specific transcription factors, and thus mediates immediate-early gene expression in response to various cell stimuli. It is most closely related to MAPK8, both of which are involved in UV radiation induced apoptosis, thought to be related to the cytochrome c-mediated cell death pathway. This gene and MAPK8 are also known as c-Jun N-terminal kinases. This kinase blocks the ubiquitination of tumor suppressor p53, and thus it increases the stability of p53 in nonstressed cells. Studies of this genes mouse counterpart suggest a key role in T-cell differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.