JNK2 Antibody Summary
| Immunogen |
Recombinant protein encompassing a sequence within the center region of human JNK2. The exact sequence is proprietary.
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| Isotype |
IgG
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| Clonality |
Polyclonal
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| Host |
Rabbit
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| Gene |
MAPK9
|
| Purity |
Immunogen affinity purified
|
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|
Applications/Dilutions
| Dilutions |
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Packaging, Storage & Formulations
| Storage |
Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
|
| Buffer |
0.1M Tris (pH 7.0), 0.1M Glycine and 10% Glycerol
|
| Preservative |
0.01% Thimerosal
|
| Concentration |
0.85 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for JNK2 Antibody
- c-Jun kinase 2
- c-Jun N-terminal kinase 2
- EC 2.7.11
- EC 2.7.11.24
- JNK2
- JNK2A
- JNK2BETA
- JNK2JNK2ALPHA
- JNK-55
- Jun kinase
- MAP kinase 9
- MAPK 9
- MAPK9
- mitogen-activated protein kinase 9
- p54a
- p54aSAPK
- PRKM9JNK2B
- SAPK
- SAPK1 alpha
- Stress-activated protein kinase JNK2
Background
JNK protein kinases are distantly related to mitogen-activated protein kinases (ERKs) and are activated by dual phosphorylation on Tyr and Thr. The JNK protein kinase group includes the 46-kDa isoform JNK1 and the 55-kDa protein kinase JNK2. The activities of both JNK isoforms are markedly increased by exposure of cells to UV radiation (1). JNK becomes activated in vivo in response to pro-inflammatory cytokines or cellular stresses. Its full activation requires the phosphorylation of a threonine and a tyrosine residue in a Thr-Pro-Tyr motif, which can be catalysed by the protein kinases mitogen-activated protein kinase kinase MKK4 and MKK7 (2). JNK2 functions in a cell-type-specific and stimulus-dependent manner, being required for apoptosis of immature thymocytes induced by anti-CD3 antibody but not for apoptosis induced by anti-Fas antibody, UVC or dexamethasone. JNK2 is not required for activation-induced cell death of mature T cells (3).