JAB1 Antibody (2A10.8) Summary
| Immunogen |
Recombinant mouse COPS5.
|
| Specificity |
The full-length mouse JAB-1 gene expressed in E. coli.
|
| Isotype |
IgG2b
|
| Clonality |
Monoclonal
|
| Host |
Mouse
|
| Gene |
COPS5
|
| Purity |
Protein G purified
|
| Innovators Reward |
Test in a species/application not listed above to receive a full credit towards a future purchase.
Learn about the Innovators Reward
|
Applications/Dilutions
| Dilutions |
|
Reactivity Notes
Please note that this antibody is reactive to Mouse and derived from the same host, Mouse. Additional Mouse on Mouse blocking steps may be required for IHC and ICC experiments. Please contact Technical Support for more information.
Packaging, Storage & Formulations
| Storage |
Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (pH 7.4)
|
| Preservative |
No Preservative
|
| Concentration |
1 mg/ml
|
| Purity |
Protein G purified
|
Alternate Names for JAB1 Antibody (2A10.8)
- COP9 constitutive photomorphogenic homolog subunit 5 (Arabidopsis)
- COP9 signalosome complex subunit 5
- COPS5
- CSN5
- CSN5COP9 (constitutive photomorphogenic, Arabidopsis, homolog) subunit 5
- EC 3.4
- JAB1
- JAB138 kDa Mov34 homolog
- Jun activation domain-binding protein 1
- MOV-34
- SGN5
- SGN5MGC3149
- Signalosome subunit 5
Background
JAB-1 is a 38 kDa protein which was originally described as a coactivator for cJUN. It is present in a large protein complex called the “”””Signalosome””””, which has been proposed to play a signaling role in mammalian cells. This protein complex appears to be analogous to the COP9 complex in plants, which is important in light-mediated plant development. Although the specific function of JAB-1 in this complex is unclear, it has recently been implicated in targeting proteins for degradation by the proteasome.