Integrin beta 3/CD61 [p Tyr773, p Tyr773] Antibody Summary
| Immunogen |
The antiserum was produced against synthesized peptide derived from human Integrin beta3 around the phosphorylation site of Tyr773. The immunogen region is: C-terminal.
|
| Modification |
p Tyr773, p Tyr773
|
| Specificity |
Integrin beta3 (Phospho-Tyr773) Antibody detects endogenous levels of Integrin beta3 only when phosphorylated at tyrosine773.
|
| Clonality |
Polyclonal
|
| Host |
Rabbit
|
| Gene |
ITGB3
|
| Purity |
Immunogen affinity purified
|
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Applications/Dilutions
| Dilutions |
|
| Theoretical MW |
87 kDa.
Disclaimer note: The observed molecular weight of the protein may vary from the listed predicted molecular weight due to post translational modifications, post translation cleavages, relative charges, and other experimental factors. |
Packaging, Storage & Formulations
| Storage |
Store at -20C. Avoid freeze-thaw cycles.
|
| Buffer |
PBS (without Mg2+ and Ca2+, pH 7.4), 0.15M NaCl and 50% Glycerol
|
| Preservative |
0.02% Sodium Azide
|
| Concentration |
1 mg/ml
|
| Purity |
Immunogen affinity purified
|
Alternate Names for Integrin beta 3/CD61 [p Tyr773, p Tyr773] Antibody
- CD61 antigen
- CD61
- GP3A
- GP3Aplatelet glycoprotein IIIa
- GPIIIA
- GPIIIaintegrin beta-3
- INGRB3
- Integrin beta 3
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
- ITG B3
- ITGB3
- Platelet membrane glycoprotein IIIa
Background
CD61 is a 110 kD integrin β chain also known as β_3 integrin or gpIIIa. It associates with the integrin α_v chain (CD51) to form the vitronectin receptor. In addition, CD61 can associate with the integrin α_IIb chain (CD41) to form the gpIIb/IIIa complex. CD61 is expressed on platelets, megakaryocytes, endothelium, smooth muscle, a subset of B cells, myeloid cells, osteoclasts, and mast cells. CD61, in conjunction with CD41 or CD51, mediates adhesion to fibronectin, fibrinogen, vitronectin, thrombospondin, and von Willebrand factor. Leukocyte-endothelial adhesion is mediated by the binding of α_v/β_3 integrin or vitronectin receptor to CD31 (PECAM-1). The 2C9.G2 antibody reacts with mouse and rat CD61, and is able to block ligand binding.