Integrin beta 3/CD61 Antibody (HM beta 3.1) [DyLight 350] Summary
| Immunogen |
Mouse alpha 5 beta 3 protein purified from the mouse hybridoma 2B4
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| Specificity |
NB100-65917 recognizes the murine integrin beta 3 subunit (CD61), a 90kD a type I membrane protein, which is expressed primarily on megakaryocytes, platelets, monocytes, macrophages, granulocytes and endothelial cells. CD61 associates with either the alpha IIb integrin (CD41) or the alpha V integrin (CD51) to form the platelet glycoprotein complex IIb/IIIa and the vitronectin receptor (VNR) respectively. The heterodimers formed with CD61 are receptors for a variety of ligands including fibrinogen, fibronectin, von Willebrands factor (vWF), vitronectin and thrombospondin. Clone HM beta 3-1 is reported to partially inhibit the binding of CD61 to fibronectin (1).
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| Isotype |
IgG
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| Clonality |
Monoclonal
|
| Host |
Armenian Hamster
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| Gene |
ITGB3
|
| Purity |
Protein G purified
|
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Applications/Dilutions
| Dilutions |
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| Application Notes |
Optimal dilution of this antibody should be experimentally determined.
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Packaging, Storage & Formulations
| Storage |
Store at 4C in the dark.
|
| Buffer |
50mM Sodium Borate
|
| Preservative |
0.05% Sodium Azide
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| Purity |
Protein G purified
|
Notes
Dylight (R) is a trademark of Thermo Fisher Scientific Inc. and its subsidiaries.
Alternate Names for Integrin beta 3/CD61 Antibody (HM beta 3.1) [DyLight 350]
- CD61 antigen
- CD61
- GP3A
- GP3Aplatelet glycoprotein IIIa
- GPIIIA
- GPIIIaintegrin beta-3
- INGRB3
- Integrin beta 3
- integrin, beta 3 (platelet glycoprotein IIIa, antigen CD61)
- ITG B3
- ITGB3
- Platelet membrane glycoprotein IIIa